The immunoinhibitory B7-H1 molecule as a potential target in cancer: Killing many birds with one stone

The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone.

Over expression of B7-H1 (also named PDL-1 or CD 274) molecule in cancer has been linked to worse prognosis and resistance to anti-cancer therapies in several malignancies. In this review, we update on the expression of B7-H1 molecule in solid and hematological malignancies. We also describe the possible mechanisms by which this molecule inhibits/downregulates the immune response to cancer cell...

Killing two birds with one stone.

A ‘business model’ is commonly seen as composed of two elements: a business system and a profit model. While the latter often gains the higher profile, the former is arguably the real ‘meat’ of a firm’s business model. Not only does it act as the ‘system of works’ that actually produces and delivers the firm’s products or services, it is also the locus where a firm can learn about its operation...

Rapamycin: Killing two birds with one stone

in both invertebrate and invertebrate species by modulating a number of downstream molecular pathways [1,2]. Drugs that inhibit the TOR pathway can serve as powerful tools to translate the effects of the TOR pathway on lifespan in simpler invertebrate model systems to more complex systems like mammals. One of the most promising drugs to slow aging is rapamycin, an inhibitor of TOR, which was pr...

Wikipedia and Machine Translation: killing two birds with one stone

In this paper we present the free/open-source language resources for machine translation created in OpenMT-2 wikiproject, a collaboration framework that was tested with editors of Basque Wikipedia. Post-editing of Computer Science articles has been used to improve the output of a Spanish to Basque MT system called Matxin. For the collaboration between editors and researchers, we selected a set ...

Osteoporosis and Aortic Stenosis: 'Killing Two Birds with One Stone'?